Horizontal neck wrinkles are a common aesthetic deficiency but limited treatment options exist and none have been studied with follow-ups of over 2 months.

This dual-center, retrospective case series (Apr 2016–Jan 2017) included adult patients receiving CPM-HA to treat horizontal neck wrinkles.

Patients were followed up for 40 weeks. CPM-HA treatment efficacy was evaluated through the Horizontal Neck Wrinkle Severity Scale and Global Aesthetic Improvement Scale (GAIS).

Adverse events (AEs) and pain on injection, as assessed on the visual analogue scale, were documented.

Subdermal injection of CPM-HA is safe and effective for treating horizontal neck wrinkles.

Sustained improvement of wrinkle intensity up to 36 weeks and minimal AEs with no Tyndall effect were observed.