Red breast syndrome (RBS) represents an inflammatory condition that rarely occurs in the setting of acellular dermal matrix use after prosthetic reconstruction.

It is characterized by erythema or rubor that occurs directly over the ADM, and its appearance resembles that of a cellulitis.

There have been many explanations with regard to etiology, but none have addressed the physiologic alterations leading to the onset and resolution of RBS.

RBS is postulated to be the result of lymphatic disruption and is self-limiting. Resolution is postulated to be the result of angiolymphatic regeneration and the re-establishment of lymphatic flow within the mastectomy skin flap and the ADM, resulting in the clearance of inflammatory mediators responsible for the localized erythema.