Anatomical studies have identified separate superficial and deep facial fat compartments, leading some to theorize that volume loss from the deep midface causes overlying superficial fat pseudoptosis.

Unfortunately, a paucity of evidence exists regarding whether facial fat volume is truly lost with age and, if so, whether it is lost equally or differentially from the superficial and deep compartments.

The aim of this study was to quantify volume changes occurring with age within the superficial, deep, and buccal fat compartments of the midface.

A retrospective longitudinal study was performed evaluating individuals aged 30 to 65 years who underwent facial computed tomography followed by facial computed tomography greater than or equal to 10 years later.

Superficial midface, deep midface, and buccal fat volumes were quantified using Horos radiology software.