The circadian rhythm was set into focus by awarding the Nobel Price of Physiology/Medicine to Jeffrey Hall, Michael Rosbash and Michael Young in late 2017.

Numerous publications elucidated the molecular mechanisms driving the circadian biorhythms of our body, peripheral organs and each single cell.

However, there is minor knowledge on the circadian rhythm of the skin, which has its own peripheral circadian clock in contact with cosmetic formulations.

The skin's epidermal clock is excessively influenced by environmental factors like UV radiation or modern lifestyle, which may induce epidermal jetlag.

Here, we give an overview on the current knowledge about the epidermal circadian clock and provide a cosmetic solution to protect and preserve the biorhythm of the skin.