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This paper explores the treatment of frostbite using adjuvant therapies, specifically iloprost and hyperbaric oxygen (HBO) therapy. It presents a case series of patients with varying frostbite severities, highlighting the challenges in treatment decision-making. While iloprost and HBO show potential in enhancing blood perfusion and oxygenation, their effectiveness is inconsistent, particularly in severe cases. The study underscores the need for further research to establish definitive treatment protocols, as current data is insufficient for universal recommendations.