Prepectoral breast reconstruction (PPBR) has recently been introduced to reduce postoperative pain and improve cosmetic outcomes in women having implant-based procedures.

High-quality evidence to support the practice of PPBR, however, is lacking. Pre-BRA is an IDEAL stage 2a/2b study that aimed to establish the safety, effectiveness, and stability of PPBR before definitive evaluation in an RCT.

The short-term safety endpoints at 3 months after surgery are reported here.

Consecutive patients electing to undergo immediate PPBR at participating UK centres between July 2019 and December 2020 were invited to participate.

Demographic, operative, oncology, and complication data were collected.

The primary outcome was implant loss at 3 months. Other outcomes of interest included readmission, reoperation, and infection.